People you meet “off the beaten track” tend to be more genuine, as they haven’t been hardened by years of loud tour groups and tough-bargaining backpackers.
When you change everything you eat, say, do, smell and hear at the same time, that’s called Culture Shock. The effects can be different from person to person.
But expect more severe culture shock when you return home from a world tour, than while you are travelling. ‘Home’ may not have changed, but you will have, and your home will seem different to your changed self.